There's a multiverse theory that there are many possible or existing universes with different physical constants, affecting everything from chemistry to orbital mechanics, and the reason we are having this conversation is because this universe was conducive to the formation of highly organized lifeforms capable of abstract thought.
In this line of reasoning "Why this set of constants" doesn't matter, because only the universes that could have observers would be observed.
Not on a multiverse directly, but I think there is merit to @hinkley's claim. Say there's a one trillionth chance that life forms on an earth-like planet. There are likely trillions of earth-like planets, so chances are good (given the assumptions) that life forms on (at least) one of those planets. People on that planet (Earth) will marvel that life was created and search for reasons that seem plausible and likely for life to have been created given the initial conditions, but the initial assumption that the chances were minuscule still remains.
That is to say, we may not be able to easily predict and rationalize the beginning of life based on the initial conditions of the earth, because it is likely that it was an improbable fluke. It feels like a lottery winner trying to explain how they won the lottery.
One of the things we're trying to figure out is how likely life is to form on an Earth-like planet. Of course it happened here, but we have no idea how common it is.
If we do the chemistry and figure out the mechanism and it looks like it happens all the time, then that tells us one more term in the Drake equation and gives us a reason to go check out the exoplanets.
I don’t disagree that having tighter bounds for the Drake equation is worth investing time and energy into.
I think we are going to find that the preconditions for life are quite common. The way solar fusion and supernovas work, what atoms are produced, The distribution of material and of those atoms within an accretion ring... if a planet forms at the right distance, then it will have the mix of chemical precursors.
Honestly I suspect the only thing that makes Earth rare is our freakishly large moon. If we can ever prove that life is viable on a timescale of eons on a planet without such huge tidal forces pumping the biosphere, that will be a revelation.
In this line of reasoning "Why this set of constants" doesn't matter, because only the universes that could have observers would be observed.