Am I glad I blocked my CX from 2020 very early from accessing the internet!
Looked into rooting - my old firmware would be ideal, but other than a native ambient lighting tap I don't really see anything worth my time. That model probably doesn't have a wide field mic yet to use for home automation.
Depends on what those $12 "buy" me. In Sony's case, "buying" meant "renting until Sony's license expires", which they could have displayed on the product page.
I very rarely re-watch movies within a few months. So if I buy one, I want to know that I can watch it again in one, 10 or 30 years (if the format can still be played). Which is not guaranteed even with blu-rays mostly thanks to DRM. But what I'd be buying is not having to think about any deadlines.
If I'm okay with a deadline, I might as well rent the movie for a weekend, in which case I expect it to be less than $12.
Because usually you can't study long-term effects before releasing a drug, and even then it can take a long time for them to surface.
I took antihistamines basically throughout my 20s. My allergy specialist said there's no reason not to. I developed some other issues and wanted to stop taking antihistamines to see if that would help (or get a hint whether they were causing it) - but that got me into itching hell for weeks.
In some online forums people reported the same and shared ways to get out of that "addiction" without going insane from itching.
My doctor didn't want to believe it and there was no research on it. That only appeared a few years later in the form of a paper called "Unbearable Pruritus After Withdrawal of (Levo)cetirizine" (2016). In the US, the FDA issued a warning in 2025, which is also the time when I heard about it. None of the doctors I went to back then reported this to anyone, so I'm surprised it got discovered at all.
As for my other issues I have no way of knowing whether they had anything to do with long-term antihistamine use. I'm a sample size of one, and none of the other stuff is quite as clear-cut as "unbearable itching".
I've had other issues with prescription drugs that didn't make the official list of side-effects and sometimes those side-effects don't just go away once I stop taking the drug.
That's why I'm very cautious when trying drugs I never had before, and even more so when it comes to taking them long-term.
I personally believe you are right to be weary about holding off on long term use before the long term efficacy and risk profile of a drug has been established, but GLP1 class drugs have been around for a long time now.
GLP1 agonist type incretins have been available for over 20 years at this point. The first marketing approval was in 2005 for exenatide (Byetta), indicated for T2DM. Exenatide was the first in class for GLP1 agonists. Then came Liraglutide (Victoza) for the same indication around 2010, and received marketing approval for weight loss (as Saxenda) 4 years later. After that around 2017 was semaglutide (Ozempic & Wegovy).
T2DM is a chronic disease, so patients who started exenatide had to stay on it life long.
These drugs are nothing new and were already being used for T2DM. It only caught public attention because semaglutide achieved double the mean BW loss over liraglutide, making it meaningful for weight loss. Novo Nordisk first got approval for Ozempic for T2DM in 2017 and then received approval for it to be marketed for weight loss under Wegovy only in 2021, but by then clinicians were already prescribing it off-label, strictly speaking, for weight loss.
I don't know how much we could extend this "they've been around for a long time" to tirzepatide (Eli Lilly: Mounjaro & Zepbound) because it's the first dual agonist. It targets GLP1 and GIP, and thus it's meaningfully separated from the others. This goes for retatrutide (again Eli Lilly) as well if it eventually comes to market as it would be the first triple-agonist targeting the aforementioned + GCGR, the glucagon receptor.
I presume you're referring to receptor upregulation in response to the drugs. Bear in mind as you read my comment that this isn't my primary area, and it's been a while since I last studied cell biology and signalling around G-protein coupled receptors. I also have not gone out of my way to read papers about the cell signalling pertaining to these drugs, only papers around clinical outcomes for these class of drugs.
After discontinuation, most patients regain around 60-80% of the weight they've lost with the medication - but this figure is limited to the study duration, so the weight regain might have continued beyond that. A good starting point for dipping your toes into outcomes would be the STEP and SURMOUNT trials, these were the trials they did for marketing approval. (They did multiple rounds of these, I believe STEP4 and SURMOUNT4 specifically had groups that stopped therapy mid-way).
We see this rebound effect with weight loss mediated solely via lifestyle modification as well, however. Still no idea why. Very broadly speaking, only a small proportion of obese/overweight patients will manage to keep the weight off, and the rest of the patient population tends to be divided into two groups: those who regain most of it (usually around half of the lost weight will be regained within 2 years, and 80% by follow up year 5), and those who regain more weight than they had lost. There hasn't been a way to tell preemptively which group the patient will land in at the time of beginning of lifestyle modification.
On top of this, yoyo-ing is also a phenomenon we tend to see. Obese and overweight patients who've managed to lose weight once will regain, lose again and so on. This phenomenon is associated with worse outcomes than being obese alone, so it is important to do long-horizon thinking when initiating therapy (be it lifestyle or pharmacotherapy) e.g. is the patient willing to stay on pharmacotherapy indefinitely? what about an indefinite maintenance dose if the patient succeeds with lifestyle modification alone? has the patient had lost and regained significant amount of wt prior? etc.
Do you think going thru an allergy shot regime from an MD allergy Dr is a viable alternative to actually dealing with the undelying allegie(s)? Seems like the issue is unsettled last Inchecked
Allergy immunotherapy (shots) work by gradually desensitizing the immune system for your specific allergens over several years, so yes. Some people can get to the point where they no longer need a daily antihistamine, but it's all very personalized and individual.
In any case, it's worth doing the skin prick allergy shot testing so you can have some idea of what common allergens affect you and the intensity of each.
Especially as someone outside the US, building a startup on AI sounds like a bad idea. Some AI company fails to pay their bribes on time, or your country doesn't cede territory to the US president, the AI gets yoinked and you are left with Mistral or Qwen.
(Technically that also applies to MS Teams, Google and so on and not just AI)
My current solution to this is to write more text. I guess I'm more in product design now. Instead of code I write documents with significantly less structure. I write something, ask the AI to find angles / decisions I missed and frame them as a long list of questions, and then I answer those questions. I iterate that until the AI can't find any more design decisions I need to make and starts generating. At that point I can turn to a different feature or project.
It's pretty exhausting to be honest. In the past I didn't have to know how the entire app was supposed to work. I would plan a bit, then code for a long time, test, plan some more. Sometimes I would get lost in some (enjoyable) architecture nonsense.
Now I just read and write regular text. Instead of exceptions I'm avoiding misunderstandings. It can almost feel like a flow state, so I have some hope that it'll turn into that once I get more used to it.
From what I read it's mostly a credit score and blacklist system. In the 2010s there was a project to use it to reward and punish people for some everyday stuff based on whether it did or didn't align with the party's morals, but it got scrapped. That's the part everyone thinks is going on over there.
I agree it's dystopian, but I live in Germany and we have a similar thing called "Schufa". For most people it mostly means that if they default on a credit, they'll be less likely to find an apartment. It differs from the US one in the sense that banks don't require you to get into debt before they trust you, that whole "build your credit score" nonsense.
That pot&kettle contest between the US and China is really heating up!
You might want to switch from "social credit" (which was a failed local project from over a decade ago) to "blacklist", or just criticize the overall surveillance system, which is pretty invasive.
I'm getting a bit tired of people posting on social media websites and then pretending they are not a part of them. "Reddit" did this, "HN" did that... let's just admit that we're all chronically online people who get irritated whenever we stumble out of our bubble and more than one person dares to disagree with us.
>Yeah and we'd be better off. The modern world is quantifiably worse than the world we had even 10 years ago. That includes everything in software development and computer science.
Rather than killing this comment, how about we discuss quantification? I actually feel this way too but do not talk about it too much and sort of boil it down to a combination of advancing in age + yelling at clouds and "Stop putting computers in all my stuff!".
Can we reliably quantify that "weaponized autism", i.e. the aggressive monetization of nerds by capital to squeeze profit out of every possible corner of society (as I interpret it in a broad sense), is making things worse. Is it damaging the economy for most people? Making people less happy? Decreasing net social mobility or discrimination? Lowering life expectancy?
> Can we reliably quantify that "weaponized autism", i.e. the aggressive monetization of nerds by capital to squeeze profit out of every possible corner of society
That's not what that term means.
Also that comment wasn't killed directly. That user is banned. Interestingly that was his first (attempted) post since 2022.
-> "monetization of nerds by capital to squeeze profit "
Note. In case this is read incorrectly. For the most part the nerds are not profiting. The nerds are sitting hunched over their desk being fed coffee from a feeding tube, to keep them happy while the owners make money.
And. To be more sad, these days you can't even get free coffee. Being fed free coffee and donuts, while others profit from us, is considered the golden age of computing.
We loved our cozy cells, not so much these more uncomfortable ones.
That's a redefinition of the term - while there is some merit to your interpretation, it's an already commonly used term that means something else. It'd seem to me that the modern tech is significantly less "autistic" than it used to be in the prior decades and will only continue to move in this direction; and aside of that, I'm pretty sure Netcob's "modern" was meant to mean current thousands rather than tens of years.
I feel there's reason to believe autism is one of the reasons why bits of goodness and democracy are still hanging on so tightly even in the midst of such a depressing present. (Search term: "positive nonconformity")
I think of it as a different algorithm to crawl the problem space of the real world.
In a general sense, humanity needs to be generalist (especially in the past) to accomplish all the things you need to do to stay alive. Having all 20 members of your tribe geek out and stare at a problem for 48 hours straight means a bear sneaks up and eats you. But having that one oddball (hey me) fall into a rabbit hole of observation and mental computation can lead the group out of a local maxima into a new paradigm of doing things.
The Percy Jackson series posited that in their magical world, ADHD is actually a strength on the battlefield, not a weakness.
I wonder what a book series that tried to do that with autism would look like.
(I can think of exactly one book where autism - or something close enough to it - was treated as a serious "what if" plot device, but I don't want to name it because it is a little bit of a spoiler, I guess.)
I don't think you're wrong, but I do think that the "modern" world - which I guess I'd label as anything that happened after the invention of writing and cities - really let those individuals thrive, and let their work become very useful for the world at large.
Trying to diagnose people across millennia is a fool's errand, but I'd wager a lot to say that people like Newton & Tesla were at the very least neurodivergent in some way, and they've had wildly outsized impacts on the world.
Looked into rooting - my old firmware would be ideal, but other than a native ambient lighting tap I don't really see anything worth my time. That model probably doesn't have a wide field mic yet to use for home automation.